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KMID : 0357920110450050485
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Korean Journal of Pathology
2011 Volume.45 No. 5 p.485 ~ p.490
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14-bp Insertion/Deletion Polymorphism of the HLA-G Gene in Osteosarcoma Patients
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Moon Ahrim
Na Ki-Yong
Kim Youn-Wha
Park Yong-Koo
Kim Su-Kang
Chung Joo-Ho
Olvi Liliana G.
Araujo Eduardo Santini
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Abstract
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Background: The major histocompatibility complex class I, G (human leukocyte antigen-G [HLA-G]) gene plays a vital role in the suppression of immune responses. Recently, a number of studies have reported an association between HLA-G and diseases (pregnancy complications, organ transplantation, and tumors). Some of the studies have revealed that the 14-bp insertion/deletion polymorphism might be associated with various diseases. The aim of the present study was to explore a possible influence of the 14-bp insertion/deletion polymorphism on osteosarcoma.
Methods: Genomic DNA was extracted from 75 formalin-fixed, paraffin-embedded tumor tissues derived from patients with conventional osteosarcoma (OSA) and 183 peripheral blood samples of healthy controls. Fifty-eight cases were South Korean patients with OSA and 17 cases were Argentine patients with OSA. The HLA-G 14-bp insertion/deletion polymorphism at exon 8 of the HLA-G locus was analyzed by polymerase chain reaction.
Results: There was a significantly different distribution profile for the 14-bp genotypes between the Korean OSA and Korean control groups. Specifically, there were more heterozygote 210 bp/224 bp genotypes in the Korean OSA group when compared to the Korean control group (62.1% vs 40.4%, p=0.002).
Conclusions: The results suggest that HLA-G heterozygote patients may be more susceptible to OSA in the Korean population.
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KEYWORD
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HLA-G, 14-bp insertion/deletion polymorphism, Osteosarcoma
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